Oogenesis: Matrix Revolutions

Oogenesis: Matrix Revolutions

The mechanism of egg-chamber elongation during Drosophila oogenesis has always been mysterious. A new study shows that the egg chambers spin around their long axis laying down polarised extracellular matrix, which acts as a molecular corset to restrict radial expansion.

The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.

The matrix metalloproteinase (MMP) family of Zinc dependent extracellular proteinases regulates development and physiologic events, including branching morphogenesis, angiogenesis, wound healing and extracellular matrix degradation. They are synthesized as secreted or transmembrane proenzymes and processed to an active form by the removal of an amino-terminal propeptide. MMP-2/Gelatinase A, as ...

Technological Revolutions

In skill-biased (de-skilling) technological revolutions learning investments required by new machines are greater (smaller) than those required by preexisting machines. Skill-biased (de-skilling) revolutions trigger reallocations of capital from slow(fast-) to fast(slow-) learning workers, thereby reducing the relative and absolute wages of the former. The model of skill-biased (de-skilling) re...

Philosophical Revolutions

Debating the Color Revolutions

In Lucan Way’s insightful, highly structural account of the color revolutions, they had to happen.1 Each was separately determined by the weakness of the authoritarian regimes. As Way puts it, “regime collapses have resulted more from authoritarian weakness than opposition strength” (62). For Way, it is even misleading to conceptualize these events as revolutions; they were authoritarian turnov...